Pangenotypic treatment regimens for chronic hepatitis C


Authors: Petr Urbánek
Authors‘ workplace: Interní klinika 1. LF UK a ÚVN – Vojenská fakultní nemocnice Praha
Published in: Vnitř Lék 2019; 65(9): 553-563
Category:

Overview

The treatment of chronic hepatitis C is currently based exclusively on the use of drugs from the direct-acting anti­viral class. They are substances that inhibit one of the 3 most important enzymes of the virus replication cycle. Anti­viral drugs are divided according to the target structure into 3 basic classes, further division is mainly based on the chemical structure of individual antivirals. A common feature of all the regimens is high efficiency and safety. Pangenotypic efficacy regimens are those that utilize a combination of 2 or 3 antiviral agents of different classes, and are effective for all HCV genotypes. Currently there are 3 such regimens available. Pangenotypic regimens probably represent the latest stage of development of treatment for chronic hepatitis C. The review discusses in detail the efficiency of different pangenotypic regimens in individual subgroups of patients with HCV infection. Atten­tion is primarily paid to the data bases for their use.

Keywords:

antiviral agent – chronic hepatitis C – treatment


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Diabetology Endocrinology Internal medicine
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