Presepsin in the diagnostics of sepsis


Authors: Marcela Káňová 1,2,3;  Radim Dobiáš 4,5;  Kateřina Liszková 1;  Michal Frelich 1,2;  Renáta Ječmínková 6;  Roman Kula 1,2
Authors‘ workplace: Klinika anesteziologie, resuscitace a intenzivní medicíny LF OU a FN Ostrava 1;  Katedra intenzivní medicíny, urgentní medicíny a forenzních oborů LF OU Ostrava 2;  Ústav fyziologie a patofyziologie LF OU, Ostrava 3;  Centrum klinických laboratoří, Oddělení bakteriologie a mykologie, Zdravotní ústav se sídlem v Ostravě 4;  Ústav mikrobiologie LF UP v Olomouci 5;  Oddělení centrálního příjmu, Urgentní příjem FN Ostrava 6
Published in: Vnitř Lék 2019; 65(7-8): 497-505
Category:

Overview

Sepsis remains one of the most common causes of death worldwide. It is caused by a complex of inadequate host responses to infection. It is also often difficult to distinguish sepsis from a non-infectious cause of systemic inflammatory response syndrome. Early identification of an infectious origin may dramatically help to improve the outcome and reduce mortality. That is the main reason why clinicians need fast, reliable and specific biomarkers for recognition of sepsis. Presepsin (sCD-14ST) is one of promising biomarkers, the level of which increases in response to a microbial infection in the host. As a glycoprotein expressed in the membranes of monocytes and macrophages, CD14 (cluster of differentiation 14) serves especially as a co-receptor of the lipopolysaccharide-lipopolysaccharide binding protein complexes, and activates the inflammatory cascade. Consequently, during the inflammatory reaction, sCD14-ST, known as presepsin, is cleaved away from plasma. The objective of this article is to determine the diagnostic value of presepsin in the diagnostics of sepsis, assessing its severity, and monitoring the effectiveness of therapeutic interventions, and to establish the prognostic value of this biomarker.

Keywords:

biomarkers – diagnostics – presepsin – sepsis


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