Diosmin – still an important modality in the treatment of venous insufficiency

Authors: Jiří Slíva
Authors‘ workplace: Ústav farmakologie 3. LF UK, Praha
Published in: Vnitř Lék 2019; 65(7-8): 524-526
Category: Actualities


Chronic venous insufficiency is a highly prevalent disease in the western population. Unfortunately, there is no causal treatment yet. A key role in the recommended therapeutic approaches, especially in the early stages, is the compression therapy accompanied by pharmacotherapy. This includes, inter alia, micronized diosmin. The following text summarizes the basic knowledge of its properties that determine its clinical use.


diosmin – flavonoids – chronic venous insufficiency – micronization

  1. Diosmin. European Pharmacopoeia 8.3 2015; 42974298. Dostupné z;WWW:https://www.google.com/urlsa=t;rct=jq=esrc=
    zhitiren.com%2Fuploads%2F1513840228%2FDiosmin_test_EP8.3.docx&usg=AOvVaw2HacGDz5zRMfZPZv5NicHm>. [221-2016.]
  2. Steinberg FM, Bearden MM, Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc 2003; 103(2): 215–223. Dostupné z DOI: <http://dx.doi.org/10.1053/jada.2003.50028>.
  3. Schewe T, Sadik C, Klotz LO et al. Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase. Biol Chem 2001; 382(12): 1687–1696. Dostupné z DOI: <http://dx.doi.org/10.1515/BC.2001.204>.
  4. Harnafi H, Amrani S. Flavonoids as Potent Phytochemicals in Cardiovascular Diseases Prevention. Pharmacognosy Reviews 2007; 1(2):193–202.
  5. Kanaze FI, Bounartzi MI, Georgarakis M et al. Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. Eur J Clin Nutr 2007; 61(4): 472–477. Dostupné z DOI: <http://dx.doi.org/10.1038/sj.ejcn.1602543>.
  6. Cova D, De AL, Giavarini F et al. Pharmacokinetics and metabolism of oral diosmin in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1992; 30(1): 29–33.
  7. Villa P, Cova D, De FL et al. Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Toxicology 1992; 73(2): 179–189.
  8. Diosmin Monograph. Altern Med Rev 2004; 9(3): 308–311.
  9. Diosmin Pharmconsul 500 mg . SPC 2016. Dostupné na WWW: <https://www.sukl.cz>.
  10. Chaumeil JC. Micronization: a method of improving the bioavailability of poorly soluble drugs. Methods Find.Exp Clin Pharmacol 1998; 20(3): 211–215.
  11. Garner RC, Garner JV, Gregory S et al. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J Pharm Sci 2002; 91(1): 32–40. Dostupné z DOI: <http://dx.doi.org/10.1002/jps.1168>.
Diabetology Endocrinology Internal medicine
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account